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Early data regarding the implantable cardioverter-defibrillator (ICD) was drawn primarily from uncontrolled series of patients for whom antiarrhythmic drug therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF) had failed.

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MADIT in 1996 had enrolled patients with ischemic cardiomyopathy (LVEF ≤35%) and asymptomatic, nonsustained VT who had inducible sustained VT or VF not suppressible with procainamide infusion during electrophysiology study (EPS).

Device battery longevity has also increased; early devices lasted 2 years or less, while current devices are expected to last 8 years or longer.

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